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Experimental Study of the Treatment of Transplanted Ovarian Carcinoma by Drug—carrying Microbubbles with Fitted Ultrasound<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
伍星，王志刚，张勇，许川山，冉海涛，李攀，刘亚敏，杨春江
Wu Xing，Wang Zhigang，Zhang Yong，et al Institute of Ultrasound Image，Chongqing University of Medical Science 400010 China
ABSTRACT
Objective：To study the anti—tumor effect of self—made paclitaxel—carrying liposome microbubbles（PLM） radiated by fitted ultrasound on nude mice transplanted human ovarian carcinoma.
Methods：Bearing cancer nude mice were divided into 5 groups.Each was treated in a different way as PLM with ultrasound，paclitaxel injected intravenously， lipid microbubbles with ultrasound，PLM，and normal sodium control，for continual 7 days，one time a day.The tumor volumes and weights were measured and tumor inhibition rate was calculated by weight.The expression of vascular endothelial growth factor（VEGF） was detected by immunohistochemistry.
Results：Tumor volumes，weights and VEGF expression differ significantly among 5 groups（P＜0.01）.The inhibition rate of PLM with ultrasound group was the biggest，and the tumor volumeand VEGF level of the group were the lowest. Conclusions：PLM radiated by fitted ultrasound could effectively inhibit tumor growth in vitro，which might developto
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