The primary study of multi-slice dynamic CT perfusion for NPC <?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

苏丹柯

Su danke

 (CT Department, Affiliated tumor Hospital of Guangxi Madical University, Nanning 530021 China )

Abstract

Objective:  To study the perfusion parameters and the time-density curves （TDC）features of local different structures of pre-radiotherapy and post-radiotherapy nasopharyngeal carcinoma (NPC) cases, and stress to investigate their values in differential diagnosis of NPC local recur patients from local radiofibrosis patients.

Methods:  Dynamic CT scan was performed on 71 objectives: 14 in local recur group, 22 in radiofibrosis group, 15 in pre-radiotherapy NPC group and 20 in control group, the TDC and the data of perfusion parameters were recorded and analyzed statistically。

　　Results: The TDC feature between local recur group, pre-radiotherapy NPC group and radiofibrosis group, control group had difference. The average of Blood Flow had significant differences by two- by – two comparison in four groups (P<0.01). Except for the control group and radiofibrosis group, the average of Blood Volume and Permeability Surface had statistical differences (P<0.01). While in Mean Transit Time, the significant differences between the control group and other three groups were only found. Conclusions The TDC and perfusion parameters of local different structures of pre-radiotherapy and post-radiotherapy NPC had different characteristics, which were helpful for the differential diagnosis of post-radiotherapy local recur patients and local radiofibrosis patients.

Keywords:   Perfusion; NPC; Multi-slice helical CT