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5-Fu白芨微球动脉内化疗栓塞治疗原发性肝癌的初步临床应用

时间:2006-10-11 21:07:16  来源:  作者:

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Intraarterial Chemoembolization with 5-Fu Bletilla Microspheres in Treatment of Primary Hepatic Carcinoma

 

郑传胜 冯敢生 李欣 梁惠民 周国锋 吴汉平

华中科技大学同济医学院附属协和医院放射科,武汉 430022

Chuan-sheng Zheng,Gan-sheng Feng,Xin Li,et al.

Department of Radiology,Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science Technology,Wuhan,Hubei Province 430022

 

ABSTRACT

  Objective:To investigate the clinical therapeutic effects and complications of 5-Fu bletilla microspheres.

  methods:Intraarterial chemoembolization was performed with 5-Fu bletilla microspheres in treatment of 32 cases of primary hepatic carcinoma. After treatment,the changes of clinical symptoms,serum AFP,tumor size,survival conditions and side effects were observed. The peripheral serum concentration of 5-Fu was also examined.

  Results:The overall therapeutic effects were better with symptomatic relief in 87.5%,obvious tumor shrinkage in 62.5% and serum AFP decrease to normal level or above 50% in 75% of patients with hepatic carcinoma. The serum peak concentration of 5-Fu was lower with 20% of that of control group,the distribution and elimination half times of 5-Fu were prolonged with 3.7 times and 93.8 times of that of control group (P<0.01). The injury of hepatic function was mild and returned within 1 month, no serious complications occurred. 28 patients with hepatic carcinoma have survived for 6~26 months.

  Conclusion:5-Fu bletilla microspheres with good vascular embolization,slow-release drug and carrier targeting functions, effective and safe in use,are a kind of ideal chemoembolization agent for hepatic carcinoma.

  Key words:Bletilla;Containing――drug microspheres;

Chemoembolization;Hepatic carcinoma.

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